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Research Group Microbiology/Biohydrometallurgy
Dr. Michel Oelschlägel
Post Doc
Clemens-Winkler-Bau, room 150
+49 3731 39-2103
michel [dot] oelschlaegel [at] bio [dot] tu-freiberg [dot] de
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TUBAF
Research interests
- Sphingopyxis fribergensis - Strain and proteins
- Enzyme cascades for biotechnological application
- Gene syntheses and gene modifications
- Recombinant protein expression and optimization
- Gene-Knock-Outs
- Establishment of industrial processes based on biotechnology
- Fine chemicals, pharmaceuticals, flavours, fragrances...
- Patents
- Business founding
- Actinobacteria, mainly rhodococci (enrichment and degradation of aromatic compounds)
- Membrane-bound proteins
- Characterization of styrene oxide isomerases
- Protein biochemistry and bioanalytics
- Biotransformation and biotechnology
List of publications
- Biotechnological production processes (lecture)
- Enzymes: purification, characterization, mechanisms (lecture)
- Source-related control and treatment of mining water in Saxony (funded by Krüger foundation)
- Investigation of the microbiological community in the mine (metagenomic studies)
- Establishing a fast assay for the identification of hotspots/ metal-contaminated sites
- Investigating biotic and abiotic factors for metal release
- Styrene oxides isomerases from soil bacteria for biotechnological application (funded by DBU)
- Investigation of styrene degradation in soil bacteria
- Isolation of novel styrene-degrading microorganisms (description of the novel species Sphingopyxis fribergensis)
- Recombinant membrane protein expression
- Establishing biotechnological processes for the syntheses of phenylacetaldehydes and phenylacetic acids
- Usage of co-metabolic pathways for synthesis
- Biotechnological synthesis of aromatic carboxylic acids or aromatic alcohols from natural resources (funded by DBU)
- Usage of natural or recombinant enzyme cascades for biosyntheses
- Gene syntheses and gene modifications, promoter construction
- Whole-cell biocatalysis
- Establishment of bioprocesses for industrial applications (E. coli, Pseudomonas fluorescens, ...)
- Gene-Knock-Outs in pseudomonads and E. coli
- Optimization of co-metabolic processes
- Fermenter-based cultivation and transformation
- Production of antioxidants for industrial applications (funded by Krüger foundation)
- Establishing industrial processes for antioxidant production
- Up-scaling and downstream-development
- Establishing an economic strategy for an industrial application of the processes and products (business plan)
- Genetic optimization of biocatalysts by constructing expression cassettes and genes
- Production of caffeic acid for the synthesis of a novel and sustainable antioxidant (funded by SMWA, EFRE and Krüger foundation)
- Screening for plants with important target compounds + investigating level of useful ingredients during vegetation period to estimate harvest time
- Organization of open-field and glashouse cultivation with partners using selected plants
- Establishing methods to isolate + enzymatically transform plant ingredients into caffeic acid and to purify the acid obtained
- Up-scaling process and purification, e.g. by preparative HPLC
- Using the self-produced "green" caffeic acid as a basis for antioxidant synthesis + establishing a complete and up-scaled process
- Carrying out market analyzes and surveys to estimate the economic potential of the process
- Economic analysis of the entire process including cost-analysis
| 2011-2014 | Ph.D scholarship from the Deutsche Bundesstiftung Umwelt (DBU) | |
| 2015 | Ph.D award "Bernhard von Cotta Preis" of the "Verein der Freunde und Förderer der TU Bergakademie Freiberg e.V." | |
| 2016 | Award for the best theses on the topic "resource efficiency" (in Saxony) awarded by the "Dresdner Gesprächskreis der Wirtschaft und der Wissenschaft e.V." |
- Student research project (2009): Identifikation des Styrolabbaus in Rhodococcus opacus 1CP. - Identification of the styrene metabolism in Rhodococcus opacus 1CP.
- Diploma project (2010): Anreicherung und biochemische Charakterisierung der Styroloxid-Isomerase aus Rhodococcus opacus 1CP. - Enrichment and biochemical characterization of the styrene oxide isomerase from Rhodococcus opacus 1CP.
- Dissertation (2015): Identification of bacterial styrene oxide isomerases and evaluation of their applicability for the environment-friendly synthesis of phenylacetaldehydes.
Study and Professional background
| since 2021 | Scientist at Environmental Microbiology Group, TUBAF, Validation-Project, funded by SMWA, EFRE and Krüger foundation (head of the project) |
| 2019-2020 | Scientist at Environmental Microbiology Group, TUBAF, Krüger-Project (head of the project) |
| since 2018 | Lecturer at the TUBAF |
| 2015-2017 | Scientist at Environmental Microbiology Group, TUBAF, DBU-Project (head of the project) |
| 2015 | Graduation: Dr. rer. nat., TUBAF |
| 2011-2015 | Ph.D.: at Environmental Microbiology Group, TUBAF, DBU-Scholarship |
| 2010 | Graduation: Dipl.-Nat., TUBAF |
| 2008 | Study: Environmental Microbiology / Biotechnology, TUBAF |
| 2005-2010 | Study: Applied Natural Science, TU Bergakademie Freiberg (TUBAF) |