Dr. Oelschlägel

Dr. Michel Oelschlägel

Dr. Michel Oelschlägel


Research Group Environmental Microbiology

Leipziger Str. 29, EG, Zimmer 14

Telefon +49 3731 392325
michel [dot] oelschlaegelatioez [dot] tu-freiberg [dot] de



Publication list

Research interests

  • Sphingopyxis fribergensis - Strain and proteins
  • Enzyme cascades for biotechnological application
  • Gene syntheses and gene modifications
  • Recombinant protein expression and optimization
  • Gene-Knock-Outs
  • Establishment of industrial processes based on biotechnology
  • Fine chemicals, pharmaceuticals, flavours, fragrances...
  • Patents
  • Business founding
  • Actinobacteria, mainly rhodococci (enrichment and degradation of aromatic compounds)
  • Membrane-bound proteins
  • Characterization of styrene oxide isomerases
  • Protein biochemistry and bioanalytics
  • Biotransformation and biotechnology

Research projects

  • Styrene oxides isomerases from soil bacteria for biotechnological application (funded by DBU)
    - Investigation of styrene degradation in soil bacteria
    - Isolation of novel styrene-degrading microorganisms (description of the novel species Sphingopyxis fribergensis)
    - Recombinant membrane protein expression
    - Establishing biotechnological processes for the syntheses of phenylacetaldehydes and phenylacetic acids
    - Usage of co-metabolic pathways for synthesis
  • Biotechnological synthesis of aromatic carboxylic acids or aromatic alcohols from natural resources (funded by DBU)
    - Usage of natural or recombinant enzyme cascades for biosyntheses
    - Gene syntheses and gene modifications, promoter construction
    - Whole-cell biocatalysis
    - Establishment of bioprocesses for industrial applications (E. coli, Pseudomonas fluorescens, ...)
    - Gene-Knock-Outs in pseudomonads and E. coli
    - Optimization of co-metabolic processes
    - Fermenter-based cultivation and transformation

  • Production of antioxidants for industrial applications (funded by Krüger foundation)
    - Establishing industrial processes for antioxidant production
    - Up-scaling and downstream-development
    - Establishing an economic strategy for an industrial application of the processes and products (business plan)
    - Genetic optimization of biocatalysts by constructing expression cassettes and genes

Courses

  • Biotechnological production processes (lecture)
  • Enzymes: purification, characterization, mechanisms (lecture)

Vitae

1987 Born in Erlabrunn
1993-2005 School
2005 General qualification for university entrance (Abitur)
2005-2010 Study: Applied Natural Science, TU Bergakademie Freiberg (TUBAF)
2008 Study: Environmental Microbiology / Biotechnology, TUBAF
2010 Graduation: Dipl.-Nat., TUBAF
2011-2015 Ph.D.: at Environmental Microbiology Group, TUBAF, DBU-Scholarship
2015 Graduation: Dr. rer. nat., TUBAF
2015-2017 Scientist at Environmental Microbiology Group, TUBAF, DBU-Project
2018-2020 Lecturer at the TUBAF
2019-2020 Scientist at Environmental Microbiology Group, TUBAF, Krüger-Project (head of the project)

Awards and Scholarships

2011-2014 Ph.D scholarship from the Deutsche Bundesstiftung Umwelt (DBU)
2015 Ph.D award "Bernhard von Cotta Preis" of the "Verein der Freunde und Förderer der TU Bergakademie Freiberg e.V."
2016 Award for the best theses on the topic "resource efficiency" (in Saxony) awarded by the "Dresdner Gesprächskreis der Wirtschaft und der Wissenschaft e.V."

Theses

  • Student research project (2009): Identifikation des Styrolabbaus in Rhodococcus opacus 1CP. - Identification of the styrene metabolism in Rhodococcus opacus 1CP.
  • Diploma project (2010): Anreicherung und biochemische Charakterisierung der Styroloxid-Isomerase aus Rhodococcus opacus 1CP. - Enrichment and biochemical characterization of the styrene oxide isomerase from Rhodococcus opacus 1CP.
  • Dissertation (2015): Identification of bacterial styrene oxide isomerases and evaluation of their applicability for the environment-friendly synthesis of phenylacetaldehydes.

Memberships (research societies)