The Biosensorics working group at the Institute of Electronic and Sensor Materials is involved in the development of aptamer and protein biosensors. The developed aptamer biosensors will later be used for the detection of antibiotics and endocrine disruptors. Enzyme and antibody biosensors are used to detect metabolic biomarkers for a wide variety of diseases, e.g. choline for cancer detection or cytokines for the detection of the body's immune response.
The most important step in the construction of a biosensor is the immobilization of the biologically active component (enzymes, proteins, antibodies, aptamers) on the sensor surface. For immobilization, different surfaces (glass, silicon, gold, ceramic, paper) are modified by different methods and materials. In this process, a suitable surface chemistry (or surface functionalization) is realized on different substrates before the binding of the biologically active component is performed.
Detection of the biomarker is then done by mass-sensitive, optical, electrical or electrochemical methods.